(+)-Solketal → HCID 178426657, compound

HRID 2037330Notes

Reaction equation

[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][O:8][C:9]2[C:18]([CH3:19])=[CH:17][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:11][C:10]=2[CH3:20])[CH2:4][O:3]1.CC1(C)O[C@@H](CO)CO1>>[CH3:1][C:2]1([CH3:21])[O:6][C@@H:5]([CH2:7][O:8][C:9]2[C:10]([CH3:20])=[CH:11][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:17][C:18]=2[CH3:19])[CH2:4][O:3]1

Participants

Reactant 2

HCID 736057(+)-Solketal

HCID 178426655HCID 178426655, compound

Product 1

HCID 178426657HCID 178426657, compound

Procedure

The title compound is prepared in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine using (S)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol; LC-MS: tR=0.67 min, [M+1]+=295.01.

Sources & evidence

ORD record: ord-7a3b21a9f928450388913420d64f8b15
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575200B2

Reaction notes

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