6-Isobutyl-4-methoxy-pyridine-2-carboxylic acid → 4-[5-(6-Isobutyl-4-methoxy-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

Participants

Reaction Steps

The title compound is prepared in analogy to Example 2 starting from 6-isobutyl-4-methoxy-pyridine-2-carboxylic acid and 4,N-dihydroxy-3,5-dimethyl-benzamidine; LC-MS: tR=1.01 min, [M+H]+=354.28; 1H NMR (CDCl3): δ 0.99 (d, J=6.8 Hz, 6H), 2.19-2.28 (m, 1H), 2.35 (s, 6H), 2.78 (d, J=7.5 Hz, 2H), 3.98 (s, 3H), 4.96 (s, 1H), 6.85 (d, J=2.3 Hz, 1H), 7.70 (d, J=2.3 Hz, 1H), 7.88 (s, 2H).

Provenance & Evidence