5-Isobutyl-4-methylpyridine-2-carboxylic acid → 2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol

HRID 2037365Notes

Reaction equation

HRID 2037365 reaction equation
[CH2:1]([C:5]1[C:6]([CH3:14])=[CH:7][C:8]([C:11]([OH:13])=O)=[N:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3].[CH2:15]([C:17]1[CH:18]=[C:19]([CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[C:20]([NH:22]O)=[NH:21])[CH3:16]>>[CH2:15]([C:17]1[CH:18]=[C:19]([C:20]2[N:22]=[C:11]([C:8]3[CH:7]=[C:6]([CH3:14])[C:5]([CH2:1][CH:2]([CH3:3])[CH3:4])=[CH:10][N:9]=3)[O:13][N:21]=2)[CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[CH3:16]

Participants

3

Reactant 2

HCID 584180455-Isobutyl-4-methylpyridine-2-carboxylic acidHCID 178436626HCID 178436626, compound

Product 1

HCID 1363440752-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol

Procedure

The title compound is prepared in analogy to Example 2 starting from 5-isobutyl-4-methyl-pyridine-2-carboxylic acid and 3-ethyl-4,N-dihydroxy-5-methyl-benzamidine; LC-MS: tR=1.12 min, [M+H]+=352.12.

Sources & evidence

ORD record
ord-009f1f54ceb34fb59d2bb3c26aee0219
Source dataset
uspto-grants-2013_11
Patent number
US08575200B2

Reaction notes

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