Tert-butyl 3-aminopropanoate hydrochloride → HCID 68630997, compound

HRID 2037368Notes

Reaction equation

HRID 2037368 reaction equation
Cl.[C:2]([O:6][C:7](=[O:11])[CH2:8][CH2:9][NH2:10])([CH3:5])([CH3:4])[CH3:3].[CH2:12]([C:14]1[CH:19]=[C:18]([C:20]2[N:24]=[C:23]([C:25]3[CH:30]=[C:29]([CH3:31])[C:28]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:27][N:26]=3)[O:22][N:21]=2)[CH:17]=[C:16]([CH3:36])[C:15]=1[CH2:37][CH2:38][C:39](O)=[O:40])[CH3:13]>>[C:2]([O:6][C:7](=[O:11])[CH2:8][CH2:9][NH:10][C:39](=[O:40])[CH2:38][CH2:37][C:15]1[C:16]([CH3:36])=[CH:17][C:18]([C:20]2[N:24]=[C:23]([C:25]3[CH:30]=[C:29]([CH3:31])[C:28]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:27][N:26]=3)[O:22][N:21]=2)=[CH:19][C:14]=1[CH2:12][CH3:13])([CH3:5])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 16218890Tert-butyl 3-aminopropanoate hydrochlorideHCID 68629896HCID 68629896, compound

Product 1

HCID 68630997HCID 68630997, compound

Procedure

3-(3-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionylamino)-propionic acid tert-butyl ester is prepared in analogy to Example 37 by coupling 3-amino-propionic acid tert-butyl ester hydrochloride with 3-{2-ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid; LC-MS: tR=1.18 min, [M+H]+=535.33.

Sources & evidence

ORD record
ord-b2e91444c48d4a9d8bde3a67e5cf0707
Source dataset
uspto-grants-2013_11
Patent number
US08575200B2

Reaction notes

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