Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethylamine → Ethanesulfonic acid (2-{2-ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethylamine | HCID 44218159 | — |
| 반응물 | Ethanesulfonamide potassium salt | HCID 59645266 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethanesulfonic acid (2-{2-ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethyl)-amide | HCID 91366116 | 19.4% |
반응 단계
A solution of the methanesulfonic acid ester intermediate of Example 48 (25 mg, 53 μmol) and ethanesulfonamide potassium salt (16 mg, 106 μmol) in DMF (2 mL) is stirred at 60° C. for 18 h. The mixture is concentrated and separated by prep. HPLC to give the title compound (5 mg) as a colourless oil; LC-MS: tR=1.14 min, [M+H]+=487.14.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08575200B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-32b1c678ba0d4570a1070c70bc09d209 |
| 출처 메모 | uspto-grants-2013_11 |