Ethanesulfonamide potassium salt → Ethanesulfonic acid ((2s)-3-{2-ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-amide

Participants

Reaction Steps

A solution of the epoxide intermediate of Example 57 (step a, 25 mg, 61 μmol) and ethanesulfonamide potassium salt (27 mg, 184 μmol) in DMF (2 mL) is stirred at 60° C. for 18 h. The solvent is removed in vacuo and the crude product is purified by prep. HPLC to give the title compound (8 mg) as a colourless oil; LC-MS: tR=1.07 min, [M+H]+=517.12.

Provenance & Evidence