Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-((2s)-3-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propylamino)-propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 3-aminopropanoate hydrochloride | HCID 2734767 | — |
| 반응물 | (s)-1-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-3-methylamino-propan-2-ol | HCID 68629918 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-((2s)-3-{2-Ethyl-4-[5-(5-isobutyl-4-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propylamino)-propionic acid methyl ester | HCID 68631224 | — |
반응 단계
A solution of the epoxide intermediate of Example 57 (step a, 150 mg, 368 μmol), β-alanine methyl ester hydrochloride (113 mg, 736 μmol) and triethylamine (93 mg, 920 μmol) in methanol (5 mL) is stirred at 60° C. for 20 h. The solvent is removed in vacuo and the crude product is purified on prep. TLC plates using DCM:methanol 10:1 to give the title compound (53 mg) as a colourless oil; LC-MS: tR=0.92 min, [M+H]+=511.18.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08575200B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-ada813ea36264dcd92d44d771c3a3299 |
| 출처 메모 | uspto-grants-2013_11 |