HCID 68630969, compound → HCID 136335904, compound

HRID 2037384Notes

Reaction equation

HRID 2037384 reaction equation
Cl.[CH2:2]([CH:4]([C:7]1[N:12]=[C:11]([C:13]([OH:15])=O)[CH:10]=[C:9]([O:16][CH3:17])[CH:8]=1)[CH2:5][CH3:6])[CH3:3].[OH:18][C:19]1[C:28]([CH2:29][CH2:30][CH3:31])=[CH:27][C:22]([C:23]([NH:25]O)=[NH:24])=[CH:21][C:20]=1[CH3:32]>>[CH2:5]([CH:4]([C:7]1[N:12]=[C:11]([C:13]2[O:15][N:25]=[C:23]([C:22]3[CH:27]=[C:28]([CH2:29][CH2:30][CH3:31])[C:19]([OH:18])=[C:20]([CH3:32])[CH:21]=3)[N:24]=2)[CH:10]=[C:9]([O:16][CH3:17])[CH:8]=1)[CH2:2][CH3:3])[CH3:6]

Participants

3

Reactant 2

HCID 68630969HCID 68630969, compoundHCID 178439252HCID 178439252, compound

Product 1

HCID 136335904HCID 136335904, compoundYield 3.1%

Procedure

The title compound (3 mg) is prepared by coupling and cyclizing 6-(1-ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid hydrochloride (64 mg, 246 μmol) and 4,N-dihydroxy-3-methyl-5-propyl-benzamidine (54 mg, 259 μmol) as described in Example 1; LC-MS**: tR=0.88 min, [M+H]+=396.29.

Sources & evidence

ORD record
ord-e8e3890028a74863ae7f75bc2bcbd9d1
Source dataset
uspto-grants-2013_11
Patent number
US08575200B2

Reaction notes

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