2,4-Difluorophenylboronic acid → HCID 25182137, compound

HRID 2037403Notes

Reaction equation

HRID 2037403 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1B(O)O>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 25182014HCID 25182014, compound

Product 1

HCID 25182137HCID 25182137, compound

Procedure

The title compound was prepared following procedures analogous to those in Example 56 using 3-(4-chloropyrimidin-2-yl)-6-methyl-6-phenyl-1,3-oxazinan-2-one and 2,4-difluorophenylboronic acid. LC-MS Method 3, tR=1.238 min, m/z=785. 1H NMR (CDCl3) 1.80 (s, 3H), 2.48-2.53 (m, 1H), 2.62-2.71 (m, 1H), 3.58-3.67 (m, 1H), 4.35-4.45 (m, 1H), 6.93-7.08 (m, 2H), 7.30-7.48 (m, 5H), 7.62-7.65 (m, 1H), 8.15-8.23 (m, 1H), 8.78-8.81 (m, 1H).

Sources & evidence

ORD record
ord-ede6eae4568942629cd4ae798c9e8d17
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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