2,6-Dichlorobenzeneboronic acid → HCID 25182135, compound

HRID 2037404Notes

Reaction equation

HRID 2037404 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1.[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=1B(O)O>>[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=1[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1

Participants

3

Reactant 2

HCID 27343322,6-Dichlorobenzeneboronic acidHCID 25182014HCID 25182014, compound

Product 1

HCID 25182135HCID 25182135, compound

Procedure

The title compound was prepared following procedures analogous to those in Example 56 using 3-(4-chloropyrimidin-2-yl)-6-methyl-6-phenyl-1,3-oxazinan-2-one and 2,6-dichlorophenylboronic acid. LC-MS Method 3, tR=1.317 min, m/z=414. 1H NMR (CDCl3) 1.70 (s, 3H), 2.30-2.40 (m, 1H), 2.48-2.52 (m, 1H), 3.47-3.51 (m, 1H), 4.10-4.15 (m, 1H), 7.10-7.40 (m, 10H), 8.78-8.79 (m, 1H).

Sources & evidence

ORD record
ord-d7624a093395410191ce8e8db89ea52e
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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