4-Fluorophenylboronic acid → HCID 25182136, compound

HRID 2037405Notes

Reaction equation

HRID 2037405 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1.[F:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:28]=[CH:27][C:26]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([N:8]3[CH2:13][CH2:12][C:11]([CH3:20])([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:10][C:9]3=[O:21])[N:3]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 25182014HCID 25182014, compound

Product 1

HCID 25182136HCID 25182136, compound

Procedure

The title compound was prepared following procedures analogous to those in Example 56 using 3-(4-chloropyrimidin-2-yl)-6-methyl-6-phenyl-1,3-oxazinan-2-one and 4-fluorophenylboronic acid. LC-MS Method 3, tR=1.193 min, m/z=363.9. 1H NMR (CDCl3) 1.60 (s, 1H), 1.80 (s, 3H), 2.48-2.53 (m, 1H), 2.62-2.71 (m, 1H), 3.60-3.67 (m, 1H), 4.30-4.40 (m, 1H), 7.20-7.55 (m, 10H), 7.60-7.62 (m, 1H), 8.05-8.15 (m, 3H), 8.80-8.85 (m, 1H).

Sources & evidence

ORD record
ord-ad3880af5ab54f0ca68ebbc76c2e62dc
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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