3-Fluorophenylboronic acid → HCID 25182138, compound

HRID 2037406Notes

Reaction equation

HRID 2037406 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[N:3]=1.[F:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1>>[F:22][C:23]1[CH:28]=[C:27]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([N:8]3[CH2:13][CH2:12][C:11]([CH3:20])([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:10][C:9]3=[O:21])[N:3]=2)[CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 25182014HCID 25182014, compound

Product 1

HCID 25182138HCID 25182138, compound

Procedure

The title compound was prepared following procedures analogous to those in Example 56 using 3-(4-chloropyrimidin-2-yl)-6-methyl-6-phenyl-1,3-oxazinan-2-one and 3-fluorophenylboronic acid. LC-MS Method 3, tR=1.215 min, m/z=749. 1H NMR (CDCl3) 1.80 (s, 3H), 2.48-2.53 (m, 1H), 2.62-2.71 (m, 1H), 3.58-3.67 (m, 1H), 4.30-4.40 (m, 1H), 7.30-7.65 (m, 10H), 7.80-7.90 (m, 2H), 8.90-8.95 (m, 1H).

Sources & evidence

ORD record
ord-f4b6ef9bd3c4463c911d0aa4fc206c2a
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

Loading…