Hydrochloric Acid → HCID 66857551, compound

Participants

Reaction Steps

A mixture of ethyl 2-(3-((S)-1-((R/S)-6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenoxy)acetate (0.0587 g, 0.148 mmol) and lithium hydroxide monohydrate (0.4275 g, 10.2 mmol) in THF (10 mL) and H2O (10 mL) was vigorously stirred at rt for 2 d. The mixture was treated with 1 N HCl (30 mL), extracted with EtOAc (3×), dried over Na2SO4. After the solvents were evaporated, the crude product was directly used in the next step without further purification. LC-MS tR=1.48 min in 3 min chromatography, m/z 370 (MH+).

Provenance & Evidence