Potassium Carbonate → HCID 25182555, compound

Participants

Reaction Steps

A 100-mL of flask was charged with 3-(2′,4′-difluorobiphenyl-3-yl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one (1 g, 2.4 mmol) dissolved in acetone (10 mL). Jones reagent (CrO3: 1 g; H2SO4: 1 mL, H2O: 4 mL) was added at 0° C. under N2 protection. The mixture was stirred overnight at rt. Aqueous K2CO3 (5 mL) was added and the mixture was extracted with EtOAc (3×15 mL). The organic layers were combined, washed with brine, dried over Na2SO4, filtered and concentrated. The residue (1.03 g) was used directly for the next step.

Provenance & Evidence