4-Fluorophenylboronic acid → HCID 58109269, compound

HRID 2037436Notes

Reaction equation

HRID 2037436 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C:13]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)([CH2:16][CH2:17][OH:18])[O:12][C:11]2=[O:26])[CH3:9])=[CH:4][CH:3]=1.[F:27][C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1>>[F:27][C:28]1[CH:33]=[CH:32][C:31]([C:2]2[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]3[CH2:15][CH2:14][C:13]([C:19]4[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=4)([CH2:16][CH2:17][OH:18])[O:12][C:11]3=[O:26])[CH3:9])=[CH:4][CH:3]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 58109117HCID 58109117, compound

Product 1

HCID 58109269HCID 58109269, compound

Procedure

The title compound was prepared from 3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one by application of procedures analogous to those described in Example 75 Step 1 using 4-fluorophenylboronic acid. The isomers were separated by chromatography on silica gel.

Workup

  1. customThe isomers were separated by chromatography on silica gel

Sources & evidence

ORD record
ord-dec19cbc59c74d1d813d4ef8b8f30143
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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