HCID 58109676, compound → HCID 58109274, compound

Participants

Reaction Steps

To a stirred solution of 2-((S)-3-((S)-1-(2′,4′-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)acetaldehyde in THF (3 mL) was added MeMgBr (1.4 M in toluene/THF, 3 mL, 4.2 mmol) at 0° C. The mixture was warmed up to rt and stirred for 1.5 h before quenching with satd aq NH4Cl (3 mL). The mixture was diluted with CH2Cl2 and dried over Na2SO4. Removal of the solvent gave the crude alcohol as a mixture of diastereomers.

Provenance & Evidence