Methylamine → HCID 53473395, compound

Participants

Reaction Steps

The title compound was prepared from 3-((R)-3-((S)-1-(2′,4′-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propanoic acid following a procedure analogous to that described in Example 76 using methylamine in place of ammonia. LC-MS Method 3 tR=1.249 min, m/z=497.2; 1H NMR (CD3OD) 1.51 (m, 3H), 1.97 (s, 1H), 2.07-2.31 (m, 6H), 2.64-2.74 (s, 3H), 2.94 (d, 1H), 5.62 (m, 1H), 6.13 (s, 1H), 6.79-6.89 (m, 2H), 6.97 (m, 4H), 7.15 (s, 2H), 7.23 (m, 3H).

Provenance & Evidence