4-Fluorophenylboronic acid → HCID 58109578, compound

HRID 2037460Notes

Reaction equation

HRID 2037460 reaction equation
[CH2:1]([C:4]1([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16](Br)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[F:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[CH2:1]([C:4]1([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([C:29]3[CH:30]=[CH:31][C:26]([F:25])=[CH:27][CH:28]=3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 58109316HCID 58109316, compound

Product 1

HCID 58109578HCID 58109578, compound

Procedure

The two diastereomers of the title compound were prepared separately from the diastereomers of 6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-(thiophen-2-yl)-1,3-oxazinan-2-one following a procedure analogous to that described in Example 111 using 4-fluorophenylboronic acid. The diastereomers were separated.

Workup

  1. customThe diastereomers were separated

Sources & evidence

ORD record
ord-0dbb7e7a2f3d4b79b1c50cc31aa138c7
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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