Sodium hydride → HCID 58109416, compound

Participants

Reaction Steps

To a solution of methyl (S)-1-(4-bromophenyl)ethyl(4-(4-fluorophenyl)-4-hydroxyhept-6-en-2-yl)carbamate (20 mg, 0.043 mmol) was added NaH at 0° C. The mixture was stirred and heated to reflux for 1 h. The mixture was cooled to rt and quenched with water. The organic phase was extracted by EtOAc and concentrated to give the crude product which was purified by preparative TLC to give three isomers of 6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-4-methyl-1,3-oxazinan-2-one.

Provenance & Evidence