Ethylene Glycol → HCID 10560027, compound

Participants

Reaction Steps

To a solution of 4-methyl-3-oxo-pentanoic acid ethyl ester (79 g, 0.5 mol) and ethane-1,2-diol (62 g, 1 mol) in toluene (1600 mL) was added TsOH (1.9 g, 0.1 mol). The mixture was refluxed till the reaction was over. The mixture was concentrated in vacuum to give the crude (2-isopropyl-[1,3]dioxolan-2-yl)-acetic acid ethyl ester (83 g, crude), which was used for the next step without further purification.

Provenance & Evidence