Sodium borohydride → 2-[2-(Propan-2-yl)-1,3-dioxolan-2-yl]ethan-1-ol

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Reaction Steps

To a solution of (2-isopropyl-[1,3]dioxolan-2-yl)-acetic acid ethyl ester (83 g, 0.41 mol) in MeOH (1600 mL) was added NaBH4 (78 g, 2.05 mol) and ZnCl2 (8.3 g). The mixture was stirred overnight. The mixture was concentrated, and the residue was dissolved in the mixture of EtOAc and water. The layers were separated, and the aqueous layer was extracted with EtOAc. The combined organic phase was dried over Na2SO4, and concentrated to give the crude product, which was purified by column to give 2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethanol (30 g, crude).

Provenance & Evidence