HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (S)-3-(1-(4-bromophenyl)ethylamino)-1-(2-fluorophenyl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| Reactant | 3-(Dimethylamino)-1-(2-fluorophenyl)propan-1-one | HCID 58109172 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-3-(1-(4-bromophenyl)ethylamino)-1-(2-fluorophenyl)propan-1-one | HCID 59635692 | 3.3% |
Reaction Steps
A solution of 3-dimethylamino-1-(2-fluoro-phenyl)-propan-1-one (17 g, 0.087 mol) and (S)-1-(4-bromophenyl)ethanamine (17 g, 0.087 mol) in EtOH (50 mL)/H2O (50 mL) was refluxed at 80° C. over night. The solvent was removed under vacuum. The residue was purified by column chromatography to afford (S)-3-(1-(4-bromophenyl)ethylamino)-1-(2-fluorophenyl)propan-1-one (1 g, 3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575156B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-95a3d59f718d4beda48091a9ffa1e10f |
| Source note | uspto-grants-2013_11 |