Azido(trimethyl)stannane → HCID 178461654, compound

Participants

Reaction Steps

To a solution of 3-((R)-3-((S)-1-(2′,4′-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propanenitrile (40 mg, 0.086 mmol) in anhydrous toluene (3 mL) was added Me3SnN3 (89 mg, 0.43 mmol) at 0° C. The mixture was refluxed overnight. The solvent was removed under reduced pressure and the residue was purified by preparative TLC to afford (R)-6-(2-(1H-tetrazol-5-yl)ethyl)-3-((S)-1-(2′,4′-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one (10 mg, yield: 22%). 1H NMR (CDCl3): 1.20 (m, 3H), 1.73-1.88 (m, 1H), 1.91-2.07 (m, 4H), 2.20-2.31 (m, 1H), 2.58-2.77 (m, 2H), 5.43 (m, 1H), 6.67-6.90 (m, 7H), 7.01 (m, 2H), 7.11 (m, 2H), 7.18 (m, 1H).

Provenance & Evidence