Dimethylamine → HCID 58109348, compound

HRID 2037541Notes

Reaction equation

HRID 2037541 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([N:17]2[CH2:22][CH2:21][C@@:20]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)([CH2:23][CH:24]3[CH2:26][O:25]3)[O:19][C:18]2=[O:34])[CH3:16])=[CH:11][CH:10]=1.[CH3:35][NH:36][CH3:37]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([N:17]2[CH2:22][CH2:21][C@:20]([CH2:23][CH:24]([OH:25])[CH2:26][N:36]([CH3:37])[CH3:35])([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[O:19][C:18]2=[O:34])[CH3:16])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 58109705HCID 58109705, compound

Product 1

HCID 58109348HCID 58109348, compound

Procedure

The title compound was prepared from (6S)-3-((S)-1-(2′,4′-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-6-(oxiran-2-ylmethyl)-1,3-oxazinan-2-one and dimethylamine following a procedure analogous to that described in Example 265 Step 2. Two isomers were isolated.

Workup

  1. customTwo isomers were isolated

Sources & evidence

ORD record
ord-545661d403a54f5fa1c1e18b2efe03b3
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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