Triethylamine → HCID 58109289, compound

Participants

Reaction Steps

To a solution of 3-(4-fluorophenyl)-1-((S)-1-(3-fluorophenyl)ethylamino)hex-5-en-3-ol (350 mg, 1.1 mmol) and Et3N (333 mg, 3.3 mmol) in anhydrous CH2Cl2 (6 mL) was added triphosgene (155 mg, 0.52 mmol) in portions at 0° C. under N2. Then the solution was refluxed overnight. After the solvent was removed under reduced pressure, the residue was purified by preparative TLC to afford (R)-6-allyl-6-(4-fluorophenyl)-3-((S)-1-(3-fluorophenyl)ethyl)-1,3-oxazinan-2-one (80 mg, 21%).

Provenance & Evidence