HCID 58109684, compound → HCID 58109426, compound

Participants

Reaction Steps

To a solution of (R)-3-((S)-1-(4-(2-hydroxyethyl)phenyl)ethyl)-6-(3-(4-methoxybenzyloxy)propyl)-6-phenyl-1,3-oxazinan-2-one (260 mg, 0.517 mmol) in acetone (2 mL) was added Jones reagent (0.25 mL, 2.5 mol/L), and the formed mixture was stirred for 30 min. The mixture was extracted with EtOAc. The combined organic layer was concentrated to give crude 2-(4-((S)-1-((R)-6-(3-(4-methoxybenzyloxy)propyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)acetic acid (260 mg, 97%), which was used for the next step without purification.

Provenance & Evidence