2-Chloro-4'-fluoropropiophenone → HCID 58109412, compound

HRID 2037574Notes

Reaction equation

HRID 2037574 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5].[CH2:13]([Mg]Br)[CH2:14][CH:15]=[CH2:16]>>[Cl:1][CH2:2][CH2:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)([OH:5])[CH2:16][CH2:15][CH:14]=[CH2:13]

Participants

3

Reactant 2

HCID 676722-Chloro-4'-fluoropropiophenoneHCID 178418797HCID 178418797, compound

Product 1

HCID 58109412HCID 58109412, compound

Procedure

1-chloro-3-(4-fluorophenyl)hept-6-en-3-ol was prepared from 3-chloro-1-(4-fluorophenyl)propan-1-one and 3-butenylmagnesium bromide following a procedure analogous to that described in Example 110 Step 1.

Sources & evidence

ORD record
ord-0fd52a71deeb46e19afc136722646550
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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