HCID 58109412, compound → HCID 58109287, compound

HRID 2037575Notes

Reaction equation

HRID 2037575 reaction equation
Cl[CH2:2][CH2:3][C:4]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)([OH:9])[CH2:5][CH2:6][CH:7]=[CH2:8].[F:17][CH:18]([F:31])[O:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([N:28]=[C:29]=[O:30])[CH3:27])=[CH:22][CH:21]=1>>[CH2:5]([C:4]1([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[O:9][C:29](=[O:30])[N:28]([C@H:26]([C:23]2[CH:24]=[CH:25][C:20]([O:19][CH:18]([F:17])[F:31])=[CH:21][CH:22]=2)[CH3:27])[CH2:2][CH2:3]1)[CH2:6][CH:7]=[CH2:8]

Participants

3

Reactant 2

HCID 58109412HCID 58109412, compoundHCID 86649949HCID 86649949, compound

Product 1

HCID 58109287HCID 58109287, compound

Procedure

6-(but-3-enyl)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one was prepared from 1-chloro-3-(4-fluorophenyl)hept-6-en-3-ol and (S)-1-(difluoromethoxy)-4-(1-isocyanatoethyl)benzene following a procedure analogous to that described in Example 110 Step 2. Two isomers were isolated.

Workup

  1. customTwo isomers were isolated

Sources & evidence

ORD record
ord-30a2075177c2451696dcf6877be88ef3
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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