Dimethylformamide → HCID 58109136, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-6-allyl-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one (379 mg, 1 mmol) in DMF were added CuCl (227 mg, 2.3 mmol) and PdCl2 (53 mg, 0.3 mmol) at 0° C. under O2, and the mixture was stirred overnight at 30° C. The mixture was washed with water and extracted with EtOAc. The organic layer was separated, and concentrated to give the crude product, which was purified by preparative TLC to afford (S)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-6-(2-oxopropyl)-6-phenyl-1,3-oxazinan-2-one (180 mg, 50%).

Provenance & Evidence