Ethyl pivaloylacetate → HCID 58109494, compound

HRID 2037580Notes

Reaction equation

HRID 2037580 reaction equation
CC(C)(C)C(=O)CC(OCC)=[O:6].[CH2:13]([C:16]1([C:32]([CH3:35])([CH3:34])[CH3:33])[O:21][C:20](=[O:22])[N:19]([C@H:23]([C:25]2[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=2)[CH3:24])[CH2:18][CH2:17]1)[CH:14]=[CH2:15]>>[CH2:13]([C:16]1([C:32]([CH3:33])([CH3:35])[CH3:34])[O:21][C:20](=[O:22])[N:19]([C@H:23]([C:25]2[CH:26]=[CH:27][C:28]([Br:31])=[CH:29][CH:30]=2)[CH3:24])[CH2:18][CH2:17]1)[CH:14]=[CH2:15].[Br:31][C:28]1[CH:27]=[CH:26][C:25]([C@@H:23]([N:19]2[CH2:18][CH2:17][C:16]([C:32]([CH3:34])([CH3:33])[CH3:35])([CH2:13][CH2:14][CH2:15][OH:6])[O:21][C:20]2=[O:22])[CH3:24])=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 86950Ethyl pivaloylacetateHCID 66857381HCID 66857381, compound

Product 2

HCID 58109494HCID 58109494, compoundHCID 66857381HCID 66857381, compound

Procedure

6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-tert-butyl-1,3-oxazinan-2-one was prepared from ethyl 4,4-dimethyl-3-oxopentanoate following procedures analogous to those described in Example 207 Steps 1 to 8. The title compound was prepared from 6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-tert-butyl-1,3-oxazinan-2-one following procedures analogous to those described in Example 78. Two isomers were isolated.

Workup

  1. customTwo isomers were isolated

Sources & evidence

ORD record
ord-a547a587c6cc4781bcf8f0b6781ac981
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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