Trifluoroacetic acid → HCID 58109296, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 3-((R)-6-allyl-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate (700 mg, 1.67 mmol) in CH2Cl2 (16 mL) was added TFA (3.2 mL) at 0° C. The mixture was stirred at rt for 2 h. Then aqueous solution of NaHCO3 was added, and the mixture was extracted with CH2Cl2. The organic layer was dried over Na2SO4 and concentrated. The residue was purified by preparative TLC to give (R)-6-allyl-6-(4-fluorophenyl)-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one (530 mg, 100%).

Provenance & Evidence