Benzyl Bromide → HCID 58109649, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-6-allyl-6-(4-fluorophenyl)-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one (530 mg, 1.67 mmol) in DMF (10 mL) was added benzyl bromide (573 mg, 3.35 mmol) and K2CO3 (924 mg, 6.7 mmol), and the mixture was heated to 80° C. for 5 hours. The reaction was quenched by H2O. The layers were separated, and the aqueous phase was extracted with CH2Cl2. The combined organic layer was dried over Na2SO4 and concentrated. The residue was purified by preparative TLC to give (R)-6-allyl-3-((S)-1-benzylpiperidin-3-yl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one (90 mg, 13%).

Provenance & Evidence