Potassium Carbonate → HCID 58109443, compound

Participants

Reaction Steps

3-((R)-3-((S)-1-(3-bromophenyl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propyl methanesulfonate (6.8 mg, 0.013 mmol) was diluted with acetonitrile (2 mL), added K2CO3 (10 mg, excess) and methanesulfonamide (2.5 mg, 2 equiv.). The mixture was stirred overnight at rt. After filtration and concentration, the residue was purified by preparative HPLC to afford N-(3-((R)-3-((S)-1-(3-bromophenyl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propyl)methanesulfonamide (2.5 mg, 37%). LC-MS (3 min) tR=1.87 min, m/z=514, 516 (M+1). 1H NMR (CDCl3) 7.31 (m, 1H), 7.23 (m, 2H), 7.14-7.05 (m, 3H), 7.02 (t, 1H), 6.87 (d, 1H), 5.64 (q, 1H), 4.17 (m, 2H), 2.97 (s, 3H), 2.33-2.11 (m, 3H), 1.52 (d, 3H).

Provenance & Evidence