Triphenylphosphine → HCID 58109155, compound

Participants

Reaction Steps

Ozone was passed into a solution of (R)-6-allyl-6-(4-fluorophenyl)-3-((S)-1-(4-fluorophenyl)ethyl)-1,3-oxazinan-2-one (500 mg, 1.40 mmol) in anhydrous CH2Cl2 (20 mL) at −78° C. until a blue color appeared. Then Ph3P (920 mg, 3.5 mmol) was added at −78° C. The formed mixture was stirred overnight. The mixture was concentrated to give crude 2-((S)-6-(4-fluorophenyl)-3-((S)-1-(4-fluorophenyl)ethyl)-2-oxo-1,3-oxazinan-6-yl)acetaldehyde, which was used for the next step without purification.

Provenance & Evidence