3-Fluoropyrrolidine → HCID 58109352, compound

Participants

Reaction Steps

The title compound was prepared from (S)-3-((S)-1-(4′-fluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one following procedures analogous to those described in Example 178 using (R)-3-fluoropyrrolidine in Step 2. LC-MS Method 2 tR=1.2 min, m/z=509.1; 1H NMR (CDCl3) 0.67-0.86 (m, 1H), 1.47 (d, 6H), 1.87-2.34 (m, 7H), 2.70-2.91 (m, 3H), 5.00-5.23 (d, 2H), 5.63 (m, 1H), 6.92-7.06 (m, 6H), 7.25 (m, 4H), 7.39 (m, 2H).

Provenance & Evidence