tert-Butanol → HCID 58109510, compound

Participants

Reaction Steps

The title compound was prepared from 3-((R)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propanamide following a procedure analogous to that described in Example 612 using t-butanol as solvent followed by treatment with 2 N aq HCl/CH3CN at rt. LC-MS Method 1 tR=1.41 min, m/z=449, 451 (M+1); 1H NMR (CD3OD) 7.28-7.20 (m, 4H), 7.04 (t, J=8.6 Hz, 2H), 6.96 (d, J=8.2 Hz, 2H), 5.46 (q, J=7.0 Hz, 1H), 2.99-2.94 (m, 1H), 2.34-2.28 (m, 3H), 2.16-2.07 (m, 2H), 1.43 (d, J=7.0 Hz, 3H), 1.13 (s, 3H), 0.90 (s, 3H).

Provenance & Evidence