2,2,2-Trifluoroethyl trifluoromethanesulfonate → 4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

HRID 2037780Notes

Reaction equation

HRID 2037780 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.FC(F)(F)S(O[CH2:15][C:16]([F:19])([F:18])[F:17])(=O)=O>>[I:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:4](=[O:8])[CH:3]=1

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 205825354-Iodo-1,2-dihydropyridin-2-one

Product 1

HCID 667369834-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

Procedure

4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one was prepared from 4-iodopyridin-2(1H)-one and 2,2,2-trifluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 628 Step 1.

Sources & evidence

ORD record
ord-9a2d404878a04101bb47989d7396cf0c
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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