HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-BroMo-N,N-diMethyl-5-thiazolecarboxaMide → HCID 58109454, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-BroMo-N,N-diMethyl-5-thiazolecarboxaMide | HCID 20482368 | — |
| Reactant | (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)-1,3-oxazinan-2-one | HCID 66600802 | — |
| Product | HCID 58109454 | HCID 58109454 | — |
Reaction Steps
The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)-1,3-oxazinan-2-one and 2-bromo-N,N-dimethylthiazole-5-carboxamide following a procedure analogous to that described in Example 459 Step 4. LC-MS Method 2 tR=1.215 min, m/z=450.1; 1H NMR (CD3OD) 0.92 (s, 3H), 1.22 (s, 3H), 1.53 (d, 3H), 2.11 (s, 2H), 2.19-2.28 (m, 1H), 2.40-2.58 (m, 2H), 3.00-3.31 (m, 4H), 5.56 (m, 1H), 7.02 (d, 2H), 7.26-7.39 (m, 5H), 7.69 (d, 2H), 8.08 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575156B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-8256a3105ad24837876c373d0e4261e4 |
| Source note | uspto-grants-2013_11 |