HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Chloro-2,4-dimethylpyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3(2H)-Pyridazinone, 6-chloro-4-methyl- | HCID 164886 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Chloro-2,4-dimethylpyridazin-3(2H)-one | HCID 59845973 | — |
Reaction Steps
Methyl iodide (1.3 mL) was added to a mixture of 6-chloro-4-methyl-2H-pyridazin-3-one (2.70 g) and K2CO3 (3.40 g) in dimethylformamide (27 mL). The resulting mixture was stirred at ambient temperature overnight. Then, water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with water and brine and dried (MgSO4). After removal of the solvent, the title compound was obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575156B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-9d0806810f3a4123b4a5756b93626030 |
| Source note | uspto-grants-2013_11 |