反应详情

温度

150 °C

3-[(S)-1-(3′,4′-Diamino-biphenyl-4-yl)-ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one (120 mg) taken up in acetic acid (2 mL) was stirred under microwave irradiation at 150° C. for 30 min. After cooling to ambient temperature, the mixture was concentrated under reduced pressure and the residue was purified by HPLC on reversed phase (MeCN/H2O) to afford the title compound.

1. temperatureAfter cooling to ambient temperature
2. concentrationthe mixture was concentrated under reduced pressure
3. customthe residue was purified by HPLC on reversed phase (MeCN/H2O)