Diazomethane → Methyl 2,2-dimethylbut-3-ynoate

Participants

Reaction Steps

To a solution of diazomethane (−10 g) in ether (400 mL) was added dropwise 2,2-dimethyl-but-3-ynoic acid (10.5 g, 93.7 mmol) at 0° C. The mixture was warmed to room temperature and stirred overnight. The mixture was distilled under atmospheric pressure to give crude methyl 2,2-dimethylbut-3-ynoate (14 g), which was used directly in the next step. 1 H NMR (400 MHz, CDCl3) δ 3.76(s, 3 H), 2.28(s, 1 H), 1.50(s, 6 H).

Provenance & Evidence