Potassium Hydroxide → HCID 59129248, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(benzo[d][1,3]dioxol-5-yl)-N-(2-(4-cyano-2-methylbutan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (0.060 g, 0.15 mmol) and KOH (0.081 g, 1.5 mmol) in 50% EtOH/water (2 mL) was heated in the microwave at 100° C. for 1 h. The solvent was evaporated under reduced pressure. The crude product was dissolved in DMSO (1 mL), filtered, and purified by reverse phase preparative HPLC to give 4-(5-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-1H-indol-2-yl)-4-methylpentanoic acid. 1 H NMR (400 MHz, DMSO-d6) δ 11.98(s, 1H), 10.79(s, 1H), 8.44(s, 1H), 7.56(s, 1H), 7.15(d, J=8.6 Hz, 1H), 7.03-6.90(m, 4H), 6.05(s, 1H), 6.02(s, 2H), 1.97-1.87(m, 4H), 1.41-1.38(m, 2 H), 1.30(s, 6 H), 1.04-1.02(m, 2H).

Provenance & Evidence