N-methyldiaminoethylamine → HCID 178429407, compound

HRID 2038152Notes

Reaction equation

HRID 2038152 reaction equation
[N:1]1([C:6]([NH:8][C:9]2[NH:10][C:11]([CH3:16])=[CH:12][C:13](=[O:15])[N:14]=2)=[O:7])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:17][NH:18][CH2:19][CH:20](N)N>ClCCl>[CH3:2][N:3]([CH2:4][CH2:5][NH:1][C:6]([NH:8][C:17]1[NH:18][C:19]([CH3:20])=[CH:12][C:13](=[O:15])[N:14]=1)=[O:7])[CH2:4][CH2:5][NH:1][C:6]([NH:8][C:9]1[NH:10][C:11]([CH3:16])=[CH:12][C:13](=[O:15])[N:14]=1)=[O:7]

Participants

4

Reactant 2

HCID 57077427N-methyldiaminoethylamineHCID 178429402HCID 178429402, compound

Product 1

HCID 178429407HCID 178429407, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone (136 mmol) prepared according to the procedure described by Meijer et al., J. Am. Chem. Soc. 2003, 125, p. 6860 are added to a solution of 0.81 g of N-methyldiaminoethylamine (6.8 mmol) in 150 ml of dichloromethane. The solution is stirred at reflux for 4.5 hours. The product is precipitated from acetone, filtered off and washed with acetone, and then dried under reduced pressure.

Workup

  1. temperatureat reflux for 4.5 hours
  2. customThe product is precipitated from acetone
  3. filtrationfiltered off
  4. washwashed with acetone
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-f7e338553daf4af886cdecca32f74038
Source dataset
uspto-grants-2013_11
Patent number
US08575341B2

Reaction notes

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