Cyanuric chloride → HCID 178429403, compound

Participants

Reaction Steps

An aqueous solution (40 ml) containing 6 ml of diisopropylethylamine and 5 g (0.018 mol) of 1-(4-aminobutyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea, prepared beforehand, was added, dropwise, to 5 g (0.018 mol) of cyanuryl chloride suspended in 80 ml of acetonitrile, at a temperature of −20° C. The reaction medium was stirred for 12 hours at ambient temperature and then poured into 200 ml of ice-cold water. The precipitate formed was filtered off and then dried under vacuum, so as to give 6.8 g (0.0175 mol) of a yellow powder with a yield of 97%.

Provenance & Evidence