p-Toluenesulfonic acid → 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Participants

Reaction Conditions

Reaction Steps

To 2,6-dichloropurine (commercially available, for example, from Aldrich) (25.0 g) was added ethyl acetate (260 mL), followed by p-toluenesulfonic acid (0.253 g). The mixture was heated to 50° C. and then 3,4-dihydro-2H-pyran (commercially available, for example, from Aldrich) (16.8 g) was added. The reaction mixture was then heated at 50° C. for 4 hours. The reaction mixture was evaporated in vacuo to give the title compound as a yellow solid (36.9 g).

Provenance & Evidence