Butylamine → HCID 57699665, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (for example, as prepared for Intermediate 2) (10 g) in dry ethylene glycol (commercially available, for example, from Aldrich) (50 mL) at room temperature and under nitrogen was added n-butylamine (commercially available, for example, from Aldrich) (16 mL) in one go. The reaction was heated at 120° C. overnight. The reaction was cooled to room temperature, diluted with ethyl acetate (150 mL) and washed with water (2×50 mL). The organic layer was dried over MgSO4, filtered and concentrated in vacuo. This afforded the title compound as a viscous green oil (10.2 g) that was used in the next step without further purification.

Provenance & Evidence