Benzyl 3-(2-hydroxyethyl)piperidine-1-carboxylate → Benzyl 3-(2-bromoethyl)piperidine-1-carboxylate

HRID 2038167Notes

Reaction equation

HRID 2038167 reaction equation
[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])[CH2:25]1>>[Br:1][CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])[CH2:25]1

Participants

3

Reactant 2

HCID 13971207Benzyl 3-(2-hydroxyethyl)piperidine-1-carboxylate2×HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306150Benzyl 3-(2-bromoethyl)piperidine-1-carboxylate

Procedure

Prepared similarly to Intermediate 10 from phenylmethyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate (for example, as prepared for Intermediate 15).

Sources & evidence

ORD record
ord-1ed850e3e8564846a4069bbf9b8ee4be
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

Loading…