Benzyl 3-(3-hydroxypropyl)piperidine-1-carboxylate → Benzyl 3-(3-bromopropyl)piperidine-1-carboxylate

HRID 2038169Notes

Reaction equation

HRID 2038169 reaction equation
[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][N:27]([C:31]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:32])[CH2:26]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][N:27]([C:31]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:32])[CH2:26]1

Participants

3

Reactant 2

HCID 58306111Benzyl 3-(3-hydroxypropyl)piperidine-1-carboxylate2×HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306103Benzyl 3-(3-bromopropyl)piperidine-1-carboxylate

Procedure

Prepared similarly to Intermediate 10 from phenylmethyl 3-(3-hydroxypropyl)-1-piperidinecarboxylate (for example, as prepared for Intermediate 19).

Sources & evidence

ORD record
ord-f29b7a0ee3004d7c9cc177ab217f7c03
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

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