Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate → Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

HRID 2038171Notes

Reaction equation

HRID 2038171 reaction equation
[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1

Participants

3

Reactant 2

HCID 58306139Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate2×HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306246Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 10 from phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate (for example, as prepared for Intermediate 23).

Sources & evidence

ORD record
ord-bb17b09370034ba3986c47d9233c0fe2
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

Loading…