5-(1-Benzyloxycarbonyl-4-piperidyl)pentanol → Phenylmethyl 4-(5-bromopentyl)-1-piperidinecarboxylate

HRID 2038174Notes

Reaction equation

HRID 2038174 reaction equation
[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])[CH2:29][CH2:28]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 140469305-(1-Benzyloxycarbonyl-4-piperidyl)pentanolHCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306239Phenylmethyl 4-(5-bromopentyl)-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 10 from phenylmethyl 4-(5-hydroxypentyl)-1-piperidinecarboxylate (for a preparation, see Chem. Pharm. Bull., 1986, 34(9), 3747-3761)

Workup

  1. customfor a preparation

Sources & evidence

ORD record
ord-f8e56971c791427196197fee303f4909
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

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